The San Francisco 49ers and the Los Angeles Rams have one of the oldest rivalries in the NFL. These two teams play in the same division, the NFC West, so they meet at least twice every season. Every game between them is important. Fans always want to know who played well and who had a bad day. In this article, we will look at player stats from their most recent matchups, talk about the history between the two teams, and explain what makes this rivalry so exciting.
A Quick Look at the Rivalry
The 49ers and Rams have played each other 154 times, counting both regular season and playoff games. Over all these years, the 49ers hold a small edge in the series, with 79 wins compared to 72 for the Rams, and 3 games ending in a tie. This shows just how close and competitive this rivalry has been for decades.
The two teams first played each other back in 1950, when the Rams beat the 49ers 35-14. Since then, both teams have moved cities and changed a lot, but the rivalry has stayed strong. They have also faced each other twice in the NFC Championship Game, which is one step before the Super Bowl. The 49ers won the first one in 1990, and the Rams won the second one in 2022, before going on to win the Super Bowl that same year.
Recap: Rams vs 49ers, November 2025
The most recent full matchup between these teams took place in November 2025 at Levi’s Stadium in Santa Clara. This game turned out to be a big win for the Rams, who beat the 49ers 42-26. It was their fourth win in a row at the time.
Quarterback Play
Matthew Stafford had a great day for the Rams. He completed 24 of his 36 passes for 280 yards and threw four touchdown passes without a single interception. This was part of a strong stretch of games for him, since he had thrown 20 touchdown passes with zero interceptions over his previous six games. Stafford also became just the ninth player in NFL history to reach 400 career touchdown passes in this game.
On the other side, the 49ers were missing their starting quarterback, Brock Purdy, who was dealing with a toe injury and had been inactive for six straight games. In his place, Mac Jones started the game and actually had a strong outing. He finished 33 of 39 passing for 319 yards, with three touchdowns and one interception. Even though Jones played well, it was not enough to stop the Rams offense.
Running Backs and Receivers
The Rams offense clicked early in this game. They scored touchdowns on their first three possessions, which had not happened for them in five years. Running back Kyren Williams was a key part of the ground game, helping the Rams control the tempo.
For the 49ers, tight end George Kittle had his best game of the season up to that point, catching 9 passes. That was more than double his previous season high of 4 receptions. Wide receiver Jauan Jennings also had a good moment, catching a 6-yard touchdown pass from Jones late in the first half. However, the 49ers also had some costly mistakes. Jennings lost a fumble deep in Rams territory, and star running back Christian McCaffrey was stopped short on a fourth-down attempt near the goal line. These mistakes made it harder for San Francisco to keep up.
Defense and Other Notes
The Rams defense also played a big role, especially in the first half, when they built a 21-0 lead early in the second quarter. Rams wide receiver Davante Adams left the game in the second half with an oblique injury, though he was hopeful it would not keep him out for long.
Recap: 49ers vs Rams, October 2025
Earlier in the 2025 season, these two teams played a Thursday Night Football game in October at SoFi Stadium in Los Angeles. This game had a different result. The 49ers won this matchup in overtime, even though Purdy was again unavailable because of his injury.
Stafford actually had a huge statistical game in this loss. He completed 30 of 47 passes for 389 yards and three touchdowns. It was one of his best performances of the season in terms of raw yardage, but turnovers hurt the Rams. Stafford lost a fumble, and running back Kyren Williams also fumbled at a costly moment. These mistakes, along with special teams issues, helped San Francisco escape with a road win despite not having their starting quarterback.
This game showed something important about the rivalry: even when one team has more individual star power on paper, small mistakes and turnovers can change the whole outcome. That is part of what makes 49ers vs Rams games so unpredictable and fun to watch.
Key Players to Watch
If you want to understand this rivalry, it helps to know the main players on each side.
San Francisco 49ers:
- Brock Purdy – The 49ers’ starting quarterback when healthy. He missed several games in 2025 due to a toe injury, but he is normally the leader of the offense.
- Christian McCaffrey – One of the best running backs in the league. He can run the ball and catch passes out of the backfield.
- George Kittle – A talented tight end who is often a top target in the passing game.
- Jauan Jennings – A reliable wide receiver who can make plays in big moments.
Los Angeles Rams:
- Matthew Stafford – An experienced quarterback who has played some of his best football against the 49ers in recent seasons.
- Kyren Williams – The Rams’ main running back, known for his ability to find the end zone.
- Puka Nacua – A young, fast-rising wide receiver who has quickly become one of Stafford’s favorite targets.
- Davante Adams – A veteran wide receiver who grew up in Northern California and has an interesting personal history with the 49ers.
Team Records and Recent Form
Over the last five seasons, the 49ers have held a small advantage in this rivalry, winning 6 out of their last 10 meetings against the Rams. Still, the Rams have won the most recent matchup and have looked strong heading into the next season, especially with Stafford playing at a high level.
Both teams have shown they can beat each other, which keeps fans on their toes every time these two meet. Injuries, like Purdy’s toe issue, also play a big part in how each game turns out. When a team’s starting quarterback is out, it usually changes the whole game plan and the final score.
What Is Next for This Rivalry
The next matchup between the 49ers and the Rams is set for September 2026. Interestingly, this game will not be played in the United States. Instead, it will take place at the Melbourne Cricket Ground in Australia, as part of the NFL’s plan to grow the game internationally. This will be a unique moment in the rivalry’s long history, since it is one of the first times these two teams will meet outside the US.
Fans on both sides will be watching closely to see if Purdy is fully healthy, how the Rams’ offense performs early in the season, and whether new storylines will develop as both teams try to win the NFC West division.
Final Thoughts
The 49ers vs Rams rivalry is one of the most exciting matchups in the NFL. Both teams have talented players, a long shared history, and a lot on the line every time they play, since they compete in the same division. Recent games have shown big performances from quarterbacks like Stafford and Jones, strong efforts from playmakers like Kittle and Williams, and costly mistakes that can flip a game in seconds. Whether you are a longtime fan or just getting into football, keeping track of player stats from these games helps you understand why this rivalry stays exciting year after year.
Frequently Asked Questions
Who has won more games in the 49ers vs Rams rivalry?
The San Francisco 49ers have the edge in the all-time series. They have won 79 games, the Rams have won 72, and 3 games have ended in a tie, across 154 total meetings.
Who had the best stats in the most recent 49ers vs Rams game?
In the November 2025 matchup, Rams quarterback Matthew Stafford had the best individual game. He threw for 280 yards and four touchdowns without any interceptions. On the 49ers’ side, Mac Jones also played well, throwing for 319 yards and three touchdowns while filling in for an injured Brock Purdy.
Where and when will the 49ers and Rams play next?
The next meeting between the two teams is scheduled for September 2026. This game will be played at the Melbourne Cricket Ground in Australia, marking a rare international matchup for this classic NFC West rivalry.
